Wednesday, March 11, 2015

Natural Alzheimer's Treatment Close to Human Trials

A natural remedy derived from a plant compound for the treatment of Alzheimer's disease is nearing clinical trials in humans. Since the plant (Ashwagandha) is considered food safe by the FDA (a.k.a., GRAS (Generally Regarded as Safe), the timeline for testing will be significantly reduced.

The early progression of Alzheimer's disease starts when a certain protein breaks apart leading to plaque formation known as BAP. This obstruction ultimately kills brain cells in the frontal lobe thereby erasing memories as it progresses onto other parts of the brain. According to chemist Muraleedharan Nair of Michigan State University, "Our studies have shown that withanamides effectively protect the brain cells by neutralizing the effect of BAP." Nair's compound accomplishes this by blocking the protein's access to neurons where the damage occurs.

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